Publications

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  1. Roper J, Yilmaz ÖH et al. Metabolic Teamwork in the Stem Cell Niche. Cell Metabolism. Volume 25, Issue 5, p993-994, 2 May 2017
  2. Roper J, Tammela T, et al. In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis. Nature Biotechnology. 2017 May 1
  3. Cheng CW and Yilmaz ÖH. Starving leukemia to induce differentiation. Nature Medicine. 2017 Jan 6;23(1):14-15. PMID: 28060803
  4. Hu B, Jin C, Li HB, Tong J, Ouyang X, Cetinbas NM, Zhu S, Strowig T, Lam FC, Zhao C, Henao-Mejia J, Yilmaz O, Fitzgerald KA, Eisenbarth SC, Elinav E, and Flavell RA. The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury. Science. 2016 Nov 11; 354(6313): 765-768. PMID:
  5. Beyaz S and Yilmaz ÖH. Dietary regulation of stemness and tumor initiation by the PPAR-d pathway. Clinical Cancer Research. 2016 Oct 4. PMID: 27702819
  6. Cetinbas NM, Sudderth J, Harris RC, Cebeci A, Negri GL, Yılmaz ÖH, DeBerardinis RJ, Sorensen PH. Glucose-dependent anaplerosis in cancer cells is required for cellular redox balance in the absence of glutamine. Sci Rep. 2016 Sep 8;6:32606. PMID: 27605385
  7. Dominguez-Brauer C, Hao Z, Elia AJ, Fortin JM, Nechanitzky R, Brauer PM, Sheng Y, Mana MD, Chio II, Haight J, Pollett A, Cairns R, Tworzyanski L, Inoue S, Reardon C, Marques A, Silvester J, Cox MA, Wakeham A, Yilmaz OH, Sabatini DM, van Es JH, Clevers H, Sato T, Mak TW. (2016) Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation. Cell Stem Cell. 2016 Aug 4;19(2):205-16. doi: 10.1016/j.stem.2016.04.002. PMID: 27184401
  8. Cangelosi A and Yilmaz ÖH. (2016) High fat diet and stem cells: Linking diet to intestinal tumor formation. Cell Cycle. Jul 2; 15(13): 1657-8. PMID: 27097128 
  9. Semir Beyaz, Miyeko D. Mana, Jatin Roper, Dmitriy Kedrin, Assieh Saadatpour, Sue-Jean Hong, Khristian E. Bauer-Rowe, Michael E. Xifaras, Adam Akkad, Luca Pinello, Yarden Katz, Shweta Shinagare, Monther Abu-Remaileh, Dudley Lamming, Rizkullah Dogum, Guoji Guo, Martin Selig, G. Petur Nielsen, Nitin Gupta, Christina Ferrone, Vikram Deshpande, Guo-Cheng Yuan, Stuart H. Orkin, David M. Sabatini, and Ömer H. Yilmaz. (2016) High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature. Mar 3
  10. Cheng CW and Yilmaz ÖH. (2015) IGFBP3 and T1D: Systemic Factors in Colonic Stem Cell Function and Diabetic Enteropathy. Cell Stem Cell. Oct 1; 17(4): 379-80. PMID: 26431180
  11. Golovko D, Kedrin D, Yilmaz ÖH, Roper J. (2015) Colorectal cancer models for novel drug discovery. Expert Opin Drug Discov.  Aug 21:1-13. [Epub ahead of print] PMID: 26295972
  12. Mihaylova MM, Sabatini DM, and Yilmaz ÖH. (2014) Dietary and Metabolic Control of Stem Cell Function in Physiology and Disease. Cell Stem Cell Mar 6;14(3):292-305. PMCID: pending
  13. Curry NL, Mino-Kenudson M, Oliver TG, Yilmaz ÖH, Yilmaz VO, Moon JY, Jacks T, Sabatini DM, Kalaany NY. (2013) PTEN-null Tumors Cohabiting the Same Lung Display Differential Akt Activation and Sensitivity to Dietary Restriction. Cancer Discov. Aug;3(8):908-21. PMCID: PMC3743121
  14. Arnason, T, Pino, M.S., Yilmaz, O., Kirley, S.D., Rueda, B.R., Chung, D.C., Zukerberg, L.R.  (2013) Cables1 is a tumor suppressor gene that regulates intestinal tumor progression in Apcmin mice. Cancer Biology & Therapy 14(7), 672-678. Jul;14(7):672-8. PMCID: PMC3742496
  15. Birsoy K, Wang T, Possemato R, Yilmaz ÖH, Koch CE, Chen WW, Hutchins AW, Gultekin Y, Peterson TR, Carette JE, Brummelkamp TR, Clish CB, Sabatini DM. (2013) MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors. Nature Genetics 2013 Jan;45(1):104-8. PMCID: PMC3530647
  16. Yilmaz, Ö.H.*, Katajisto, P.*, Lamming, D.W., Gültekin, Y., Bauer-Rowe, K.E., Sengupta, S., Birsoy, K., Durun, A., Yilmaz, V.O., Selig, M., Nielsen, G.P., Mino-Kenudson, M., Zukerberg, L.R, Bhan, A.K., Deshpande, V., and Sabatini, D.M. (2012) mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake. Nature Jun 28;486(7404):490-5. PMCID: PMC3387287
  17. Kelly, P.J., Shinagare, S., Sainani, N., Hong, X., Ferrone, C., Yilmaz, O., Fernandez-Del Castillo, C., Lauwers, G.Y., Deshpande, V. (2012) Cystic Papillary Pattern in Pancreatic Ductal Adenocarcinoma: A Heretofore Undescribed Morphologic Pattern That Mimics Intraductal Papillary Mucinous Carcinoma. Am J Surg Pathol. 36(5) 696-701.
  18. Lee, J.Y., Nakada, D., Yilmaz, Ö.H., Tothova, Z., Lim, M.S., Gilliland, D.G., Morrison, S.J. (2010) An      mTOR-induced tumor suppressor response contributes to the depletion of hematopoietic stem cells after Pten deletion. Cell Stem Cell 7(5), 593-605. PMCID: PMC2995996
  19. Oravecz-Wilson, K.I.*, Philips S.T.*, Yilmaz, Ö.H.*, Li, L., Lucas, P.C., Sitwala, K., Downing, J.R., Morrison, S.J., Ross, T.S. (2009) Persistence of Leukemia-initiating Cells in a Novel Mouse Model of Imantinib-Responsive Myeloid Leukemia. Cancer Cell 16(2): 137-148. PMCID: PMC2763369
  20. Levi, B., Yilmaz, Ö.H., Duester, G and Morrison, S.J. (2009) Aldehyde dehydrogenase 1a1 is dispensable for murine nervous and hematopoietic stem cell function. Blood 113(8), 1670-1680. PMCID: PMC2647681
  21. Kiel, M.J., Yilmaz, Ö.H., and Morrison, S.J. (2008) CD150 negative cells are transiently reconstituting multipotent progenitors with little or no stem cell activity. Blood 111(8), 4413-4414. PMCID: PMC2293285
  22. Yilmaz, Ö.H. and Morrison, S.J. (2008) The PI-3kinase pathway in hematopoietic stem cells and leukemia-initiating cells: a mechanistic difference between normal and cancer stem cells. Blood Cells Mol Dis. 41(1), 73-76. PMCID: PMC2517145
  23. Kim, I, He, S., Yilmaz, Ö.H., Kiel, M.J., and Morrison, S.J. (2006) Enhanced purification of fetal liver hematopoietic stem cells using SLAM family receptors. Blood 108(2), 737-744.  PMCID: PMC1895480
  24. Yilmaz, Ö.H., Valdez, R., Thiesen, B.K., Guo, W. Ferguson, D.O., Wu, H., and Morrison, S.J. (2006) Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature 441, 475-482. [Cover Article].
  25. Yilmaz, Ö.H., Kiel, M.J., and Morrison, S.J. (2006) SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity. Blood 107, 924-930.
  26. Kiel, M.J.*, Yilmaz, Ö.H.*, Iwashita, T.*, Terhorst, C., and Morrison, S.J. (2005). SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells. Cell 121, 1109-1121.
  27. Kim, I, Yilmaz, Ö.H., and Morrison, S.J. (2005) CD144 (VE-cadherin) is transiently expressed by fetal liver stem cells. Blood 106(3), 903-905.
  28. Kiel, M.J., Iwashita, T., Yilmaz, Ö.H., and Morrison, S.J. (2005) Spatial differences in hematopoiesis but not in stem cells indicate a lack of regional patterning in definitive hematopoietic stem cells. Dev Biol 283, 29-39.

*equal contributors, co-first authors

Book Chapters

  1. Yilmaz, Ö.H. and Deshpande, V. (2012) Pathology and Genetics of Pancreatic Neoplasms. Surgical Pathology Clinics