Select Publications

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  1. Goto, N, Goto, S, Imada, S, Hosseini, S, Deshpande, V, Yilmaz, ÖH. Lymphatics and fibroblasts support intestinal stem cells in homeostasis and injury. Cell Stem Cell. (2022) 29, 1246-1261.e6. 10.1016/j.stem.2022.06.013PMID:35931033

  2. Goto, N, Yilmaz, ÖH. Bispecific antibodies seek out colon cancer stem cells. Nat Cancer (2022) 3, 379-380. 10.1038/s43018-022-00368-zPMID:35469016

  3. Beyaz, S, Chung, C, Mou, H, Bauer-Rowe, KE, Xifaras, ME, Ergin, I, Dohnalova, L, Biton, M, Shekhar, K, Eskiocak, O et al. Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis.  Cell Stem Cell (2021) 28, 1922-1935.e5. 10.1016/j.stem.2021.08.007PMID:34529935

  4. Mana, MD, Hussey, AM, Tzouanas, CN, Imada, S, Barrera Millan, Y, Bahceci, D, Saiz, DR, Webb, AT, Lewis, CA, Carmeliet, P et al. High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity. Cell Rep (2021) 35, 109212.
    10.1016/j.celrep.2021.109212PMID:34107251

  5. Cheng, CW, Yilmaz, ÖH. 100 Years of Exploiting Diet and Nutrition for Tissue Regeneration.  Cell Stem Cell (2021) 28, 370-373.
     10.1016/j.stem.2021.02.014PMID:33667357 

  6. Calibasi-Kocal, G, Mashinchian, O, Basbinar, Y, Ellidokuz, E, Cheng, CW, Yilmaz, ÖH. Nutritional Control of Intestinal Stem Cells in Homeostasis and Tumorigenesis.  Trends Endocrinol Metab (2021) 32, 20-35. 10.1016/j.tem.2020.11.003PMID: 33277157

  7. Almeqdadi, M, Mana, MD, Roper, J, Yilmaz, ÖH. Gut organoids: mini-tissues in culture to study intestinal physiology and disease. Am J Physiol Cell Physiol (2019) 317, C405-C419. 10.1152/ajpcell.00300.2017PMID: 31216420

  8. Cheng CW, Biton M, Haber AL, Gunduz N, Eng G, Gaynor LT, Tripathi S, Calibasi-Kocal G, Rickelt S, Butty VL, Moreno-Serrano M, Iqbal AM, Bauer-Rowe KE, Imada S, Ulutas MS, Mylonas C, Whary MT, Levine SS, Basbinar Y, Hynes RO, Mino-Kenudson M, Deshpande V, Boyer LA, Fox JG, Terranova C, Rai K, Piwnica-Worms H, Mihaylova MM, Regev A, Yilmaz ÖH. Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet. Cell. 2019 Aug 22;178(5):1115-1131.e15. doi: 10.1016/j.cell.2019.07.048. PMID:  31442404

  9. Omer H. Yilmaz, Dietary regulation of the origins of cancer. AAAS Watchel Prize Essay, Science Translational Medicine. (2018) 10, 453, eaat8285. 

  10. Maria M. Mihaylova, Chia-Wei Cheng, Amanda Q. Cao, Surya Tripathi, Miyeko D. Mana, Khristian E. Bauer-Rowe, Monther Abu-Remaileh, Laura Clavain, Aysegul Erdemir, Caroline A. Lewis, Elizaveta Freinkman, Audrey S. Dickey, Albert R. La Spada, Yanmei Huang, George W. Bell, Vikram Deshpande, Peter Carmeliet, Pekka Katajisto, David Sabatini, Omer Yilmaz. Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging. Cell Stem Cell. (2018) 22, issue 5, 769-778. 

  11. Wen Zhou, Mohammad Almeqdadi,  Michael E. Xifaras,  Imogen A. Riddell,  Ömer H. Yilmaz and Stephen J. Lippard. The effect of geometric isomerism on the anticancer activity of the monofunctional platinum complex trans-[Pt(NH3)2(phenanthridine)Cl]NO3. Chemical Communications. (2018) 54, 2788-2791.

  12. Roper J, Tammela T, Akkad A, Almeqdadi M, Santos SB, Jacks T, Yilmaz ÖH  Colonoscopy-based colorectal cancer modeling in mice with CRISPR-Cas9 genome editing and organoid transplantation. Nature Protocols. (2018) 13, 217-234 . PMID:   29300388

  13. Mana MD, Kuo EY, Yilmaz ÖH  Dietary Regulation of Adult Stem Cells. Curr Stem Cell Rep. (2017) Mar 3(1):1-8. PMID:28966904

  14. Roper J, Yilmaz ÖH Metabolic Teamwork in the Stem Cell Niche. Cell Metabolism. (2017) May 2, Volume 25, Issue 5, p993-994. PMID:28467944 

  15. Roper J , Tammela T, Cetinbas NM , Akkad A, Roghanian A, Rickelt S, Almeqdadi M, Wu K, Oberli MA, Sánchez-Rivera FJ, Park YK, Liang X, Eng G, Taylor MS, Azimi R, Kedrin D, Neupane R, Beyaz S, Sicinska ET, Suarez Y, Yoo J, Chen L, Zukerberg L, Katajisto P, Deshpande V, Bass AJ, Tsichlis PN, Lees J, Langer R, Hynes RO, Chen J, Bhutkar A, Jacks T & Yilmaz ÖH  In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis. Nature Biotechnology. (2017) May 1. PMID:28459449 

  16. Cheng CW and Yilmaz ÖH Starving leukemia to induce differentiation. Nature Medicine. (2017) Jan 6;23(1):14-15. PMID: 28060803

  17. Hu B, Jin C, Li HB, Tong J, Ouyang X, Cetinbas NM, Zhu S, Strowig T, Lam FC, Zhao C, Henao-Mejia J, Yilmaz ÖH, Fitzgerald KA, Eisenbarth SC, Elinav E, and Flavell RA The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury.  Science. (2016) Nov 11; 354(6313): 765-768. PMID:  27846608

  18. Beyaz S and Yilmaz ÖH. Dietary regulation of stemness and tumor initiation by the PPAR-d pathway. Clinical Cancer Research. (2016) Oct 4. PMID: 27702819

  19. Cetinbas NM, Sudderth J, Harris RC, Cebeci A, Negri GL, Yılmaz ÖH, DeBerardinis RJ, Sorensen PH Glucose-dependent anaplerosis in cancer cells is required for cellular redox balance in the absence of glutamine.  Sci Rep. (2016) Sep 8;6:32606. PMID: 27605385

  20. Dominguez-Brauer C, Hao Z, Elia AJ, Fortin JM, Nechanitzky R, Brauer PM, Sheng Y, Mana MD, Chio II, Haight J, Pollett A, Cairns R, Tworzyanski L, Inoue S, Reardon C, Marques A, Silvester J, Cox MA, Wakeham A, Yilmaz OH, Sabatini DM, van Es JH, Clevers H, Sato T, Mak TW. (2016) Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation. Cell Stem Cell. (2016) Aug 4;19(2):205-16. PMID: 27184401

  21. Cangelosi A and Yilmaz ÖH High fat diet and stem cells: Linking diet to intestinal tumor formation.  Cell Cycle. (2016) Jul 2; 15(13): 1657-8. PMCID: PMC4957592 

  22. Beyaz S, Mana MD, Roper J, Kedrin D, Saadatpour A, Hong S-J, Bauer-Rowe KE, Xifaras ME, Akkad A, Pinello L, Katz Y, Shinagare S, Abu-Remaileh M, Lamming D, Dogum R, Guo G, Selig M, Nielsen GP, Gupta N, Ferrone C, Deshpande V, Yuan G-C, Orkin SH, Sabatini DM, and  Yilmaz ÖH High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature. (2016) Mar 3;531(7592): 53-58 PMID:  26935695

  23. Cheng CW and Yilmaz ÖH. IGFBP3 and T1D: Systemic Factors in Colonic Stem Cell Function and Diabetic Enteropathy.  Cell Stem Cell. (2015) Oct 1;17(4): 379-80 PMID:   26431180  

  24. Golovko D, Kedrin D, Yilmaz ÖH, Roper J Colorectal cancer models for novel drug discovery.  Expert Opin Drug Discov.  (2015) Aug 21:1-13. [Epub ahead of print] PMID: 26295972

  25. Mihaylova MM, Sabatini DM, and Yilmaz ÖH Dietary and Metabolic Control of Stem Cell Function in Physiology and Disease. Cell Stem Cell. (2014) Mar 6; 14(3):292-305. PMCID: PMC3992244

  26. Curry NL, Mino-Kenudson M, Oliver TG, Yilmaz ÖH, Yilmaz VO, Moon JY, Jacks T, Sabatini DM, Kalaany NY  PTEN-null Tumors Cohabiting the Same Lung Display Differential Akt Activation and Sensitivity to Dietary Restriction. Cancer Discov. (2013) Aug;3(8):908-21. PMCID: PMC3743121

  27. Arnason T, Pino MS, Yilmaz ÖH, Kirley SD, Rueda BR, Chung DC, Zukerberg LR  Cables1 is a tumor suppressor gene that regulates intestinal tumor progression in Apcmin mice.  Cancer Biology & Therapy. 14(7), 672-678. (2013) Jul;14(7):672-8. PMCID: PMC3742496

  28. Birsoy K, Wang T, Possemato R, Yilmaz ÖH, Koch CE, Chen WW, Hutchins AW, Gultekin Y, Peterson TR, Carette JE, Brummelkamp TR, Clish CB, Sabatini DM  MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors. Nature Genetics. (2013) Jan;45(1):104-8. PMCID: PMC3530647

  29. Yilmaz ÖH*, Katajisto P*, Lamming DW, Gültekin,Y, Bauer-Rowe KE, Sengupta, S, Birsoy, K, Durun, A, Yilmaz, VO, Selig M, Nielsen GP, Mino-Kenudson M, Zukerberg LR, Bhan AK, Deshpande V, and Sabatini DM mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake. Nature. (2012) Jun 28;486(7404):490-5. PMCID: PMC3387287

  30. Kelly PJ, Shinagare S, Sainani N, Hong X, Ferrone C, Yilmaz ÖH, Fernandez-Del Castillo C, Lauwers GY, Deshpande V Cystic Papillary Pattern in Pancreatic Ductal Adenocarcinoma: A Heretofore Undescribed Morphologic Pattern That Mimics Intraductal Papillary Mucinous Carcinoma.  Am J Surg Pathol. (2012) 36(5) 696-701

  31. Lee JY, Nakada D, Yilmaz ÖH, Tothova Z, Lim MS, Gilliland DG, Morrison SJ mTOR-induced tumor suppressor response contributes to the depletion of hematopoietic stem cells after Pten deletion.  Cell Stem Cell. (2010) 7(5), 593-605. PMCID: PMC2995996

  32. Oravecz-Wilson KI*, Philips ST*, Yilmaz ÖH*, Li L, Lucas PC, Sitwala K, Downing JR, Morrison SJ, Ross TS Persistence of Leukemia-initiating Cells in a Novel Mouse Model of Imantinib-Responsive Myeloid Leukemia. Cancer Cell. (2009) 16(2): 137-148. PMCID: PMC2763369

  33. Levi B, Yilmaz ÖH, Duester G and Morrison SJ Aldehyde dehydrogenase1a1 is dispensable for murine nervous and hematopoietic stem cell function. Blood. (2009) 113(8), 1670-1680. PMCID: PMC2647681

  34. Kiel MJ, Yilmaz ÖH, and Morrison SJ  CD150 negative cells are transiently reconstituting multipotent progenitors with little or no stem cell activity. Blood. (2008) 111(8), 4413-4414. PMCID: PMC2293285

  35. Yilmaz ÖH and Morrison SJ The PI-3kinase pathway in hematopoietic stem cells and leukemia-initiating cells: a mechanistic difference between normal and cancer stem cells. Blood Cells Mol Dis. (2008) 41(1), 73-76. PMCID: PMC2517145

  36. Kim I, He S, Yilmaz ÖH, Kiel MJ, and Morrison SJ Enhanced purification of fetal liver hematopoietic stem cells using SLAM family receptors. Blood. (2006) 108(2), 737-744.  PMCID: PMC1895480

  37. Yilmaz ÖH, Valdez R, Thiesen BK, Guo W, Ferguson DO, Wu H, and Morrison SJ Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature. (2006) 441, 475-482. [Cover Article]. PMID:  16598206

  38. Yilmaz ÖH, Kiel MJ, and Morrison SJ  SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity.  Blood. (2006) 107, 924-930. PMID:  16219798

  39. Kiel MJ*, Yilmaz ÖH*, Iwashita T*, Terhorst C, and Morrison SJ  SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells. Cell. (2005) 121, 1109-1121. PMID:  15989959

  40. Kim I, Yilmaz ÖH, and Morrison SJ  CD144 (VE-cadherin) is transiently expressed by fetal liver stem cells. Blood. (2005) 106(3), 903-905. PMCID:   PMC1895147

  41. Kiel MJ, Iwashita T, Yilmaz ÖH, and Morrison SJ Spatial differences in hematopoiesis but not in stem cells indicate a lack of regional patterning in definitive hematopoietic stem cells. Dev Biol. (2005) 283, 29-39. PMID:  15913595

*equal contributors, co-first authors

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Complete List of Publications